Research Platform on Biomechanics

Summary


Our Biomechanics platform is dedicated to the study of mechanical interactions within biological systems, from the cell scale to the tissue. Our research focuses on biophysical phenomena such as cell adhesion, migration, growth and morphology, and the interactions with fluid dynamics. 

Applications


- health

 

- diagnostic

 

- therapeutic tools


The platform regroups high performance tools for the characterisation of the mechanical properties of cell and tissue, for bio-rheology studies, and imaging.

Cells - Biophysics - Growth - Adhesion - Morphology - Mechanics - Fluxes

Tools and Equipement


▪ Imaging tools (confocal and atomic force microscopy): 3D study of cellular or tissue structures, imaging of moving objects, cell or tissue topology analysis

 

▪ Tools for the micro-scale characterisation of adhesion orvisco-elastic forces (AFM)

 

▪ 2D and 3Dmicroprocessing: design of microfluidic circuits, micro-structured substrates

 

▪ Environmental chambers: preparation of standardized biological material

 

▪ Microrheology tools and techniques: study of the reological properties of complex fluids (biological fluids with low stability in vitro, vesicles or microorganisms suspensions).

The confocal microscope equipped with the environmental chamber
The confocal microscope equipped with the environmental chamber
The probe tip of the AFM  (atomic force microscope)
The probe tip of the AFM (atomic force microscope)
Acoustic tweezers for the manipulation of micro-objects (© P. Thibault)
Acoustic tweezers for the manipulation of micro-objects (© P. Thibault)

Methodology


Examples of research projects


▪ Behaviour of biological fluids in model circuits or flow chambers

 

▪ Effects of fluid mechanics on the morphology of vesicles or biomimetic objects

 

▪ 2D or 3Dcell migration incontrolled–rigidity gels


Forces exerted by a migrating cell in a gel (credit: C Verdier)
Forces exerted by a migrating cell in a gel (credit: C Verdier)
Vacillating-breathing of a vesicle when its external suspending fluid is subject to shear (credit: G Coupier)
Vacillating-breathing of a vesicle when its external suspending fluid is subject to shear (credit: G Coupier)
Bacterial biofilm growth in catheters (credit: S Lecuyer)
Bacterial biofilm growth in catheters (credit: S Lecuyer)

Downloadable documents


Download
Brochure Biomechanics.pdf
Adobe Acrobat Document 429.8 KB

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