PLATFORMS

PLATFORMS

Mecanobiology

Our mecanobiology platform is dedicated to the study of mechanical interactions within biological systems, from the cell scale to the tissue. Our research focuses on biophysical phenomena such as cell adhesion, migration, growth and morphology, and the interactions with fluid dynamics.

APPLICATIONS

  • Health
  • Diagnostic
  • Therapeutic tools

TAGS

Cells - Biophysics - Growth - Adhesion - Morphology - Mechanics - Soft matter - Fluxes

DOCUMENTS

Brochure

Tools and equipment

Imaging tools (confocal and atomic force microscopy): 3D study of cellular or tissue structures, imaging of moving objects, cell or tissue topology analysis

 

Tools for the micro-scale characterisation of adhesion orvisco-elastic forces (AFM)

 

2D and 3D microprocessing: design of microfluidic circuits, micro-structured substrates

 

Environmental chambers: preparation of standardized biological material

 

Microrheology tools and techniques: study of the reological properties of complex fluids (biological fluids with low stability in vitro, vesicles or microorganisms suspensions).


The probe tip of the AFM  (atomic force microscope)
The probe tip of the AFM (atomic force microscope)
The confocal microscope equipped with the environmental chamber
The confocal microscope equipped with the environmental chamber
Acoustic tweezers for the manipulation of micro-objects (© P. Thibault)
Acoustic tweezers for the manipulation of micro-objects (© P. Thibault)

Methodology


Examples of research projects


Forces exerted by a migrating cell in a gel (credit: C Verdier)
Forces exerted by a migrating cell in a gel (credit: C Verdier)
Vacillating-breathing of a vesicle when its external suspending fluid is subject to shear (credit: G Coupier)
Vacillating-breathing of a vesicle when its external suspending fluid is subject to shear (credit: G Coupier)
Bacterial biofilm growth in catheters (credit: S Lecuyer)
Bacterial biofilm growth in catheters (credit: S Lecuyer)