PhD DEFENSE BY SYLVAIN LOSSERAND

This PhD was co-supervised by Thomas Podgorski and Gwennou Coupier (LIPhy) and financed by the CNES (French Center for Space Studies). The subject was initiated by Sylvain Losserand, Thomas Podgorski and Gwennou Coupier as part of a proof of concept project funded by Tec21 in 2015.

The defense will take place at 2 pm at the LIPhy.

Abstract

Blood is a suspension composed of about 50% of red blood cells (RBCs) which are highly deformable structures and which main function is to transport oxygen from the lungs to the organs. This PhD focuses on an essential parameter of microcirculation: the time of transit of red blood cells in an organ, this parameter being a main limitation to the diffusion and availability of oxygen. Depending on the mechanical properties of red blood cells, which can be altered by certain pathologies, and their concentration in the blood, their time of transit can vary in large proportions, some red blood cells being faster than others. The influence of different parameters and different phenomena will therefore be studied in order to have a better understanding of the time of transit of red blood cells in blood vessels.