Starting: October 2015
The fibrous microstructure of human soft tissues is responsible for a complex mechanical behavior at the macroscopic scale, highly non-linear, anisotropic and visco-hyperelastic. Since the 1960s and the boom of “bionics”, a large field of research has been developed to mimic the materials and structures of evolving systems. Nowadays, the biomimetic approach is very promising for the treatment of soft-tissue pathologies, though it still needs important progress from fundamental research, in particular when it comes to biological oscillators such as vocal folds.
The global objective of this project is to design new fibrous synthetic composites mimicking the vocal-fold histological specificities, and to study their multi-scale mechanical and vibratory properties.
(a) Scheme of a coronal view of the human larynx and zoom on the vocal-fold fibrous architecture.
(b) Photographs of wavy polyamid monofilaments (diameter 50 µm) processed to mimic collagen fibres’ tortuosity at rest (from Argoud, 2015).
(Above) Illustration of a uniaxial tensile test performed on a synthetic fibre-reinforced elastomeric membrane, typically processed for biomimetic design of human soft tissue (from Bailly et al., 2015).
Three major experimental steps are carried out:
The project associates specialists in mechanics of materials (3SR Lab), experts in voice physiology (GIPSA Lab), and surgeons from the University Hospital in Grenoble (LADAF Laboratory).
Coll. Philippe Chaffanjon, Laurent Orgéas
Oral paper 2016: Cochereau, T., Bailly, L., Orgéas L., Henrich Bernardoni, N. and Chaffanjon P. (2016). A micro-mechanical model of the vocal-fold upper layers. 22nd Congress of the European Society of Biomechanics, July 10 - 13, 2016, Lyon, France
Oral paper 2016: Bailly, L., Cochereau, T., Orgéas, L., Rolland du Roscoat, S., Henrich Bernardoni, N., Robert, Y., Chaffanjon, P., McLeer, A. (2016). De la biomécanique du pli vocal à la phonation humaine. Colloque INSIS "Comment réparer l'homme élastique ?" December 5, 2016, Paris, France (view the slides here)
Journal article 2017: Santé : les promesses de l'élasticité, Hugo Leroux, CNRS Le Journal, January 9, 2017 (read the article here)